Description
A capsaicin analog with diverse biological activities; inhibits Src in, as well as VEGF-induced proliferation of and tube formation by, HUVECs from 5-25 µM; activates TRPV1 in HEK293 cells expressing the human channel (EC50 = 290 nM) and induces) nociceptive behaviors in mice; topical application reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis; decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain at 10 mg/kg